Odwala matenda a impso (CKD) nthawi zambiri amakhala ndi hyperphosphatemia, ndipo hyperphosphatemia ya nthawi yayitali imatha kubweretsa zovuta zazikulu monga hyperparathyroidism, aimpso osteodystrophy, ndi matenda amtima. Kuwongolera kuchuluka kwa phosphorous m'magazi ndi gawo lofunikira pakuwongolera odwala CKD, ndipo zomangira phosphate ndiye mwala wapangodya wochizira hyperphosphatemia. Mzaka zaposachedwa,lanthanum carbonate, monga mtundu watsopano wa zomangira zopanda kashiamu ndi zopanda aluminium phosphate, pang'onopang'ono zalowa m'munda wa masomphenya a anthu ndikuyamba "mpikisano" ndi zomangira zachikhalidwe za phosphate.
"Zoyenera" ndi "zoyipa" za zomangira zachikhalidwe za phosphate
Zomangira za phosphate zachikhalidwe zimaphatikizanso zomanga za phosphate zomwe zimakhala ndi calcium (monga calcium carbonate ndi calcium acetate) ndi zomanga za phosphate zokhala ndi aluminiyamu (monga aluminium hydroxide). Iwo kuphatikiza phosphates chakudya kupanga insoluble mankhwala, potero kuchepetsa m`mimba mayamwidwe phosphorous.
Zomangira za phosphorous okhala ndi calcium: Mtengo wotsika komanso zotsatira zenizeni zochepetsera phosphorous, koma kugwiritsidwa ntchito kwanthawi yayitali kungayambitse hypercalcemia ndikuwonjezera chiopsezo cha kuwerengetsa kwa mitsempha.
Zomangamanga zokhala ndi phosphorous zokhala ndi aluminiyamu: Mphamvu yochepetsera phosphorous yamphamvu, koma kuchulukidwa kwa aluminiyamu kumakhala kowopsa kwambiri ndipo kungayambitse matenda a mafupa okhudzana ndi aluminiyumu ndi encephalopathy, ndipo pakadali pano sagwiritsidwa ntchito mochepera.
Lanthanum carbonate: Kukula kwatsopano, komwe kuli ndi zabwino zambiri
Lanthanum carbonate ndi carbonate ya rare earth metal element lanthanum, yokhala ndi njira yapadera yomangira phosphorous. Amatulutsa ayoni a lanthanum m'malo a acidic a m'mimba ndipo amapanga phosphate ya lanthanum yosasungunuka ndi phosphate, motero amalepheretsa kuyamwa kwa phosphorous.
Chidule chachidule cha lanthanum carbonate
| Dzina la malonda | Lanthanum carbonate |
| Fomula | La2(CO3)3.xH2O |
| CAS No. | 6487-39-4 |
| Kulemera kwa Maselo | 457.85 (ochepa) |
| Kuchulukana | 2.6g/cm3 |
| Malo osungunuka | N / A |
| Maonekedwe | White crystal ufa |
| Kusungunuka | Kusungunuka m'madzi, kusungunuka bwino mu ma mineral acids amphamvu |
| Kukhazikika | Mosavuta hygroscopic |
Poyerekeza ndi zomangira zachikhalidwe za phosphorous, lanthanum carbonate ili ndi izi:
Palibe calcium ndi aluminiyamu, chitetezo chapamwamba: Amapewa chiopsezo cha hypercalcemia ndi poizoni wa aluminiyamu, makamaka kwa odwala omwe ali ndi chithandizo cha nthawi yayitali komanso chiopsezo cha calcification ya mitsempha.
Wamphamvu phosphorous kumanga luso, phosphorous kwambiri kuchepetsa zotsatira: Lanthanum carbonate akhoza bwino kumanga phosphorous mu lonse pH osiyanasiyana, ndi kumangiriza luso ndi wamphamvu kuposa miyambo phosphorous binders.
Kuchepa kwa zilonda zam'mimba, kutsata bwino kwa odwala: Lanthanum carbonate imakoma bwino, ndi yosavuta kumwa, imakhala ndi vuto la m'mimba pang'ono, ndipo odwala amatha kumamatira ku chithandizo kwa nthawi yaitali.
Umboni wofufuza zamankhwala: Lanthanum carbonate imachita bwino
Maphunziro angapo azachipatala atsimikizira mphamvu ndi chitetezo cha lanthanum carbonate mwa odwala CKD. Kafukufuku wasonyeza kuti lanthanum carbonate si yotsika kapena yoposa zomangira zamtundu wa phosphate pochepetsa milingo ya phosphorous m'magazi, ndipo imatha kuwongolera milingo ya iPTH ndikuwongolera zizindikiro za kagayidwe ka mafupa. Kuonjezera apo, chitetezo cha chithandizo cha nthawi yaitali ndi lanthanum carbonate ndi chabwino, ndipo palibe kudzikundikira kwa lanthanum koonekeratu ndi zotsatira za poizoni zomwe zapezeka.
Chithandizo cha payekhapayekha: Sankhani dongosolo labwino kwambiri la wodwalayo
Ngakhale kuti lanthanum carbonate ili ndi ubwino wambiri, sizikutanthauza kuti ingathe kusintha zomangira zamtundu wa phosphate. Mankhwala aliwonse ali ndi zizindikiro zake ndi zotsutsana, ndipo ndondomeko ya chithandizo iyenera kukhala payekha malinga ndi momwe wodwalayo alili.
Lanthanum carbonate ndi yabwino kwa odwala awa:
Odwala omwe ali ndi hypercalcemia kapena chiopsezo cha hypercalcemia
Odwala ndi mtima calcification kapena chiopsezo mtima calcification
Odwala omwe salolera bwino kapena osagwira bwino ntchito zomangira phosphate zachikhalidwe
Zomangira zachikhalidwe za phosphate zitha kugwiritsidwabe ntchito kwa odwala awa:
Odwala omwe ali ndi zovuta zachuma
Odwala omwe sali osagwirizana ndi lanthanum carbonate
Kuyang'ana zamtsogolo: Lanthanum carbonate ili ndi tsogolo lowala
Ndi kuzama kwa kafukufuku wa zachipatala komanso kudzikundikira kwa zochitika zachipatala, momwe lanthanum carbonate pochiza hyperphosphatemia mwa odwala CKD ikukulirakulira. M'tsogolomu, lanthanum carbonate ikuyembekezeka kukhala phosphate binder yoyamba, kubweretsa uthenga wabwino kwa odwala ambiri a CKD.
Nthawi yotumiza: Mar-25-2025