National Nanocenter JACS: Ultra woonda CeO2 nano antioxidant

Anthu amawona ma oxide nanoenzymes ngati zida zoyenera kwambiri zothandizira kufananiza chithandizo cha matenda obwera chifukwa cha oxidative stress-mediated pathophysiological disorders ndi ma enzymes a antioxidant, koma chothandizira cha oxide nanoenzymes sichinali chogwira mtima.

Poganizira izi, Tang Zhiyong, Wang Hao, Xingxin Fa, Qiao Zengying, ndi ena ochokera ku National Nanometer Center adanenanso koyamba kuti zowonda kwambiri.CeO2ndi kupsinjika kwamkati kumagwiritsidwa ntchito polimbana ndi nano oxidation.

Mfundo zazikuluzikulu za nkhaniyi

Mfundo yofunika 1. Kupyolera mu mawerengedwe ongoganizira ndi kusanthula, anapeza kuti kupsyinjika pamwamba paCeO2zikugwirizana ndi kugwirizana unsaturation wa Ce ndi makulidwe aCeO2. Chifukwa chake, ma nanosheets owonda kwambiri okhala ndi makulidwe a ~ 1.2 nm adapangidwa, ndipo kupsinjika kwa ndege / kupsinjika kwa ndege kudafikira ~ 3.0% ndi ~ 10.0%, motsatana.

Mfundo yofunika 2. Poyerekeza ndi nanocubes, ultra-thin nanosheet Ce-O chemical bond yalimbikitsa mgwirizano, zomwe zimapangitsa kuti kuwonjezeka kwa 2.6 kuwonjezereka kwa SOD (superoxide dismutase) yofananitsa (superoxide dismutase) yochititsa chidwi komanso kuwonjezereka kwa 2.5 nthawi zonse mu mphamvu ya antioxidant. Kugwiritsa ntchito izi kocheperako kwambiriCeO2Kanema wokhala ndi kupsinjika kwamkati wochizira sitiroko ya ischemic mu vivo ali ndi ntchito yabwinoko kuposa mankhwala azikhalidwe azachipatala