M'zaka zaposachedwa, teknoloji ya nano-mankhwala ndi teknoloji yatsopano yodziwika bwino mu teknoloji yokonzekera mankhwala. Nano mankhwala monga nanoparticles, mpira kapena nano kapisozi nanoparticles monga chonyamulira dongosolo, ndi efficacy wa particles m'njira inayake pamodzi pambuyo mankhwala, angathenso kupanga mwachindunji processing wa nanoparticles.
Poyerekeza ndi mankhwala ochiritsira, nano-mankhwala ali ndi zabwino zambiri zomwe sizingafanane ndi mankhwala wamba:
Mankhwala omasulidwa pang'onopang'ono, kusintha theka la moyo wa mankhwala m'thupi, kuwonjezera nthawi ya mankhwala;
Chiwalo chenichenicho chikhoza kufikidwa pambuyo popangidwa kukhala mankhwala otsogolera;
Kuchepetsa Mlingo, kuchepetsa kapena kuthetsa zotsatira zoyipa potengera kuonetsetsa kuti zikuyenda bwino;
Njira yoyendetsera nembanemba imasinthidwa kuti iwonjezere kuchuluka kwa mankhwalawa ku biofilm, zomwe zimapindulitsa pakuyamwa kwa mankhwala a transdermal komanso kusewera kwamphamvu kwa mankhwalawa.
Chifukwa chake kwa omwe amafunikira mothandizidwa ndi chonyamulira kuti apereke mankhwala ku mipherezero yeniyeni, perekani gawo la chithandizo molingana ndi ma nanodrugs, kapangidwe kake konyamula kuti apititse patsogolo kuwongolera kwamankhwala ndikofunikira.
Posachedwapa nkhani nkhani anati yunivesite ya New South Wales, Australia, ofufuza anayamba njira yatsopano, akhoza kusintha mawonekedwe a nano mankhwala chonyamulira, izi zingathandize kunyamula mankhwala odana ndi khansa anamasulidwa mu chotupa, kusintha zotsatira za anti -mankhwala a khansa.
Polima mamolekyu mu njira akhoza basi kupangidwa vesicle dzenje ozungulira dongosolo polima, ali ndi ubwino wa bata amphamvu, zosiyanasiyana zinchito chimagwiritsidwa ntchito monga mankhwala chonyamulira, koma, Mosiyana, monga mabakiteriya ndi HIV mu chikhalidwe ndi machubu, ndodo. , ndipo zinthu zomwe sizikhala zozungulira zimatha kulowa m'thupi mosavuta. Chifukwa ma vesicles a polima ndi ovuta kupanga mawonekedwe osazungulira, izi zimalepheretsa polima kuti apereke mankhwala komwe akupita mthupi la munthu kumlingo wina wake.
Ofufuza aku Australia adagwiritsa ntchito ma microscopy a cryoelectron kuti awone kusintha kwa mamolekyu a polima mu yankho. Iwo adapeza kuti posintha kuchuluka kwa madzi mu zosungunulira, mawonekedwe ndi kukula kwa ma polima vesicles akhoza kusinthidwa mwa kusintha kuchuluka kwa madzi mu zosungunulira.
Wolemba wamkulu komanso yunivesite ya New South Wales Institute of chemistry ya pine parr sol, anati: "Kupambana kumeneku kumatanthauza kuti titha kupanga mawonekedwe a polymer vesicle amatha kusintha ndi chilengedwe, monga oval kapena tubular, ndi paketi yamankhwala momwemo." Umboni woyambirira umasonyeza kuti zonyamulira zachilengedwe, zosazungulira za nano-mankhwala zimatha kulowa m'maselo otupa.
Kafukufukuyu adasindikizidwa pa intaneti m'magazini yaposachedwa ya magazini ya Natural Communications.
Nthawi yotumiza: Jul-04-2022